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As far back as the 16th Century Paracelsus pioneered the view that humans must have certain balances of minerals in their body to maintain health. 

Over the last 50 years Laboratoires Bioligo and CRAO (Centre de Recherché et d’Applications sur les Oligoelements) have continued the work of several eminent and pioneering French doctors as outlined below:


  • 1895  Gabriel Bertrand (France) maintains that trace elements are vital for all living cells.


  • 1900’s Dr J. Sutter (France) student of Brown Sequard, (the father of endocrinology)) establishes a medication based on glandular extracts and ionized trace elements in very small doses. Manganese and Copper were prescribed successfully for arthritis and tuberculosis.


  • 1919   A report published by Dr Guilly, a surgeon on the battlefields during the First World War, who applied Dr Sutter’s methods of trace element therapy, recorded with photographic proof sensational results on wounds and infections.


  • 1932   As head of an important private clinic, Dr. Sutter worked with 20 trace element prescriptions which were manufactured under the direction of a first-class French chemist.  His medications were registered with Laboratoire Nationale du Controle Pharmaceutique and were readily accepted by doctors and patients alike.


  • 1946   Dr Menetrier, who is regarded as the father of Functional Medicine, progresses the work of

Dr. Sutter establishes that trace elements not only attack the symptoms but also strengthen the background condition (diathesis) of the body. He developed the association of different trace elements with different diatheses (terrain/background condition).


  • 1958-1978  Dr Picard (France) conducted successful clinical trials (50,000 cases) using trace elements to treat osteoarthritis.


  • He proved that for both healing and regeneration of joints to occur, several trace elements need to be taken simultaneously. This was a challenge because of the reactivity of trace elements. Initially, the 12 trace elements were supplied in individual glass ampoules, which was both expensive and awkward for the patients to handle. In 1973 Bioligo successfully combined all the trace elements for Dr Picard’s trials in just two complexes, ensuring that each trace element retained their individually active therapeutic action. This pioneering work gave birth to the current range of 19 Global Oligotherapy complexes. 


  • 1980   Michel Deville, Founder and Director of Centre de Recherches et d’Applications sur les Oligolements, Switzerland, creates a simplified system for Dr Picard and progresses the background conditions to include the four diatheses/ background conditions plus an additional diathesis for the endocrine system.


  • 1982-  The CRAO undertake clinical trials and research covering human, plant and animal disorders. They developed the therapy from the classical catalytic trace element therapy to the modern global trace element complexes. The Centre has also pioneered the use of catalytic trace elements having obtained recognition and registration with SwissMedic for their use in pharmacology, cosmetics and agricultural products.


The CRAO/ Bioligo’s unique history has given them a comprehensive understanding of how to administer natural remedies in the complex landscape of 21st-century health challenges. The Bioligo global trace element complexes fulfil the modern-day challenging requirements of delivering important trace elements in a potent form that is fast-acting, uniquely effective and safe for everybody including children, pregnant or lactating women, the frail and the aged.  



Michel Deville - Founder of Laboratoire Bioligo CRAO

Frédéric Deville -Director of lab & CRAO

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